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Of the total samples, 31.3% were rotavirus positive in Albania, 78.3% in the Salento, and 40.3% in Rome. The samples collected in Tirana and Rome were G�CP typed, whereas the samples collected in the Salento were only G typed. Ceramidase Overall, in Italy the most frequent combinations were G4 P (54.5%), G1 P (27.3%), and G2 P (18.2%); in Albania they were G9 P (72.1%), G4 P (8.8%), G1 P (5.9%), and G2 P (2.9%). The prevalence in Albania of atypical combinations was 7.4% for G4 P and 2.9% for G9 P. Phylogenetic analysis was also performed to assess the genetic relatedness of the strains. J. Med. Virol. 82:510�C518, 2010. ? 2010 Wiley-Liss, Inc. ""Herpes simplex virus (HSV) resistance to acyclovir or foscarnet results from mutations in viral thymidine kinase (TK) and/or DNA polymerase (pol) genes. Replication kinetics and virulence of TK and/or DNA pol clinical mutants were assessed using models of mouse encephalitis and cotton rat genital infection. Replication capacities in Vero cells of a DNA pol altered strain (L850I) and a TK/DNA pol mutant (C467deletion/A912V) were significantly lower than those of unrelated wild-type (WT) strains, while find more a double DNA pol mutant (S724N/P920S) demonstrated replication kinetics similar to the WT. The replication of a TK-deficient mutant (G439.5addition) was impaired (low m.o.i.) or unaltered (high m.o.i.) compared to that of a WT virus depending on the viral inoculum. Compared to a survival rate of 6% for mice infected intranasally with WT HSV-1 or -2 viruses, G439.5add, C467deletion/A912V and L850I strains were associated with survival rates of 100% (P?<?0.05) whereas mice infected with the S724N/P920S mutant had a survival rate of 33% (P?=?0.08). Brain viral titers were higher in mice infected with WT HSV-1 or -2 strains and the double DNA pol mutant. <a href="http://www.selleckchem.com/screening/anti-cancer-compound-library.html">Anti-cancer Compound Library clinical trial All strains except the DNA pol mutant L850I were able to establish latency in the dorsal root ganglia of cotton rats. A good correlation was generally found between replication kinetics of DNA pol mutants and their neurovirulence potential in mice whereas such correlation was not straightforward for TK mutants. J. Med. Virol. 82:1000�C1006, 2010. ? 2010 Wiley-Liss, Inc. ""The incidence of cervical cancer in Paraguay is among the highest in the world. This study aimed to determine the distribution of human papillomavirus (HPV) genotypes in Paraguayan women, according to the severity of the cervical lesion. This cross-sectional study included 207 women without a squamous intraepithelial lesion, 164 with low-grade squamous intraepithelial lesions, 74 with high-grade squamous intraepithelial lesions, and 41 with cervical cancer. Type-specific HPV was determined by the polymerase chain reaction with MY9/11 L1 and GP5+/GP6+ L1 primers, followed by restriction fragment length polymorphism and reverse line blotting hybridization, respectively.